![]() Of SCA results, 19 (61%) were reported as 45,X and 12 (39%) were SC trisomy. Of 50 abnormal cfDNA results for SC, 31 patients (62%) were positive for SCA, 13 (26%) were inconclusive, and 6 (12%) were sex discordant on US. Primary outcome was concordance with karyotype or postnatal evaluation. Cell-free DNA results were abnormal if they were positive for SC aneuploidy (SCA), inconclusive, or discordant with ultrasound (US) findings. This is a retrospective cohort study of abnormal cfDNA results for SC at a referral practice from March 2013 to July 2015. To investigate factors associated with abnormal cell-free DNA (cfDNA) results for sex chromosomes (SCs). Scibetta, Emily W Gaw, Stephanie L Rao, Rashmi R Silverman, Neil S Han, Christina S Platt, Lawrence D PMID:27992373Ĭlinical accuracy of abnormal cell-free fetal DNA results for the sex chromosomes. In this review, we will outline the current evidence on the interaction of sex chromosome abnormalities with schizophrenia, autism, ADHD and mood disorders. While studies showed evidence of susceptibility loci over many sex chromosomal regions related to various mental diseases, others demonstrated that the sex chromosome aneuploidies may be the key to exploring the pathogenesis of psychiatric disease. It remains unclear whether sex chromosome abnormalities are related to sex differences in some psychiatric diseases. Zhang, Xinzhu Yang, Jian Li, Yuhong Ma, Xin Li, RenaĮxcesses of sex chromosome abnormalities in patients with psychiatric diseases have recently been observed. Sex chromosome abnormalities and psychiatric diseases
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